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Patch-seq combined with volumetric electron microscopy has revealed cell-type-specific inhibitory connectivity profiles across transcriptomically-defined neuron populations, providing a wiring diagram of subtype selective perisomatic targeting (Gamlin et al., 2025),as illustrated in Fig. 2a. These connectivity motifs align with the projection neuron-type specific output dynamics recently characterised in motor cortex corticothalamic circuits (Li et al., 2026),as shown in Fig. 3b-e, with inhibitory inputs analysed across all cortical sections.
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